European Society for Developmental
Perinatal and Paediatric Pharmacology

28 - 30 May 2019, Basel, Switzerland

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Wednesday May 29, 2019

MONTREAL ROOM – 8:30-19:00

08:30 – 10:00: Drug development study design for rare diseases
                           Moderators: Gilbert Burckart  & Florian Lagler

08:30-09:00: Florian Lagler: Orphan drug trials in inborn errors of metabolism - Lessons learned and future challenges
09:00-09:30: Eric Hoffman: The experience with Duchenne muscular dystrophy
: Dmitry Kravtsov: Treatment of MVID – a pediatric nightmare: engaging alternative signaling pathways to bypass the genetic defect

Information about speakers:

Florian Lagler is Head of the Institute for Inherited Metabolic Diseases of Paracelsus Medical University Salzburg, CEO of the Clinical Research Centre Salzburg GmbH, and advisor for the Austrian Agency for Health and Food Safety.

Eric Hoffman is Professor of Pharmaceutical Sciences, Bingham University –SUNY, USA and CEO of ReveraGen BioPharma, Rockville, USA

Dmitry Kravtsov is Vice President Research and Development, Vanessa Research, Inc.

10:00-10:30: 3 free oral presentations
                       Moderators: Dionna Green & Kalle Hoppu
10:00-10:10: Verena Gotta: Effect of hemodialysis dose (spKt/V) on survival in patients on maintenance hemodialysis since childhood - a retrospective analysis
10:10-10:20: Pascal André: Circulating concentrations of broad-spectrum beta-lactams in children with cancer: beware of glomerular hyperfiltration!
10:20-10:30: Laura Dhondt: Piglets as animal model to assess the contribution of fluid therapy to the development of augmented renal clearance in children

10:30-11:00: Coffee, posters and networking

11:00-12:30: Hot topics in perinatal pharmacology
Moderators: Mark Turner & Karel Allegaert

11:00-11:30: Jan Bonhoeffer: Vaccinations in pregnant women
11:30-12:00: Dirk Bassler: Inhaled steroids and bronchopulmonary dysplasia
: Dick Tibboel: Evidence based pharmacotherapy for neonatal pulmonary hypertension

Information about speakers:

Jan Bonhoeffer is President of the Brighton Collaboration Foundation and Vice-Chair, Pediatric Infectious Diseases and Vaccines at the University Children’s Hospital Basel, Switzerland

Dirk Bassler is Professor and Chair of the Department of Neonatology in Zürich, Switzerland

Dick Tibboel is Professor and Director of Research Intensive Care at Erasmus MC-Sophia Children’s Hospital in Rotterdam, the Netherlands

12:30-13:00: 3 free oral presentations
                       Moderators: Dick Tibboel  & Milica Bajcetic
12:30-12:40: Paola Mian: Physiologically based pharmacokinetic modelling to characterize acetaminophen pharmacokinetics and NAPQI formation in non-pregnant and pregnant women
12:40-12:50: Gideon Koren: Fetal Outcome following Dydrogesterone Exposure in Pregnancy
12:50-13:00: Mia Nørgaard: Paternal acitretin exposure and pregnancy risks

13:00-14:30: Lunch, poster viewing session and networking

14:30-16:00: PK/PD modeling and simulations: quo vadis?
                        Moderators: Catherine Sherwin  & Catherijne Knibbe

14:30-15:00: Marc Pfister: The perspective of the academician
: Richard Peck: The perspective of the industry
15:30-16:00: Gil Burckart: The perspective of the regulatory agency

Information about speakers:

Marc Pfister is Professor of Pharmacometrics and Systems Pharmacology at the University of Basel Children’s Hospital, Basel, Switzerland

Richard Peck is Global Head Clinical Pharmacology, Pharmaceutical Sciences, Roche Pharma Research and Early Development, Roche Innovation Center, Basel, Switzerland

Gilbert Burckart is Associate Director for Pediatrics at the Center of Drug Evaluation and Research, Office of Translational Sciences, Office of Clinical Pharmacology at the FDA

16:00-16:30: Coffee, posters and networking

16:30-18:00: 9 free oral presentations
                       Moderators: Anne Smits  & Robert Flint
16:30-16:40: Laurie Conklin: Defining serum CCL22 and trefoil factor 3 (TFF3) as pharmacodynamic biomarkers for use in a proof-of-concept clinical trial of vamorolone in paediatric ulcerative colitis
16:40-16:50: Tamara van Donge: Methadone dosing strategies in preterm neonates can be simplified
16:50-17:00: Gianna Salis: Drug delivery kinetics of intravenous gentamicin in a population of neonates
17:00-17:10: Anne Smits: Improved early vancomycin exposure in neonates using a population pharmacokinetic model-based vancomycin dosing regimen
17:10-17:20: Aline Engbers: Pharmacokinetics of prophylactic and therapeutic fluconazole in preterm neonates
17:20-17:30: Angela Williams: Characterising the pharmacokinetics of phenobarbitone in neonates to facilitate future individualised dosing
17:30-17:40: Laurent Favié: Lidocaine plasma concentrations and anti-epileptic efficacy in term and preterm neonates: prospective validation of a new dosing regimen
17:40-17:50: Amita Pansari: Predictive performance of a physiologically based pharmacokinetic model of caffeine in the preterm population
17:50-18:00: Robert Flint: The bioavailability and maturing clearance of doxapram in preterm infants

18:00-19:00: ESDPPP General Assembly (by invitation only)

OSAKA ROOM – 08:30-18:00

08:30-10:00: Tools to improve clinical trials in children and adolescents?
                         Moderators: Saskia de Wildt & Pieter de Cock

08:30-09:00: Olivier Blanson Henkemans: Robotic Buddy “PAL Charly” to improve diabetic selfmanagement in children
09:00-09:30: Bruce Carleton: Using pharmacogenomics to understand drug response heterogeneity in clinical trials
: Urs Frey: Use of pulmonary function to facilitate observational studies and clinical trials

Information about speakers:

Olivier Blanson Henkemans is Senior Scientist Child Health, the Netherlands Organisation for Applied Scientific Research (TNO), the Netherlands

Urs Frey is the Chairman of Pediatrics, University of Basel Children’s Hospital, Basel, Switzerland

10:00-10:30: 3 free oral presentations
                       Moderators: Elke Krekels & Stephanie Leroux
10:00-10:10: Valentina Shakhnovich: Variability in liver anatomy and physiology in children participating in pharmacokinetic studies
10:10-10:20: Sebastiaan Goulooze: Towards personalised weaning of sedatives and analgesics using mechanism-based modelling of iatrogenic withdrawal in critically ill children
10:20-10:30: Elke H.J. Krekels: Item Response theory modeling; old kid on the block to improve pediatric drug dosing

10:30-11:00: Coffee, posters and networking

11:00-12:30: Treatment of serious infections in low and middle-income countries
                        Moderators: Natella Rakhmanina & Facundo Garcia Bournissen

11:00-11:30: Catia Marzolini: Treatment of children living with HIV
11:30-12:00: Irene Kuepfer: Treatment of children with malaria
12:00-12:30: Julia Bielicki: Treatment of children with bacterial infections

Information about speakers:

Catia Marzolini is a PharmD, PhD in the Division of Infectious Diseases and Hospital Epidemiology, University of Basel, Switzerland

Irene Kuepfer is Assistant Professor at the London School of Hygiene and Tropical Medicine, UK and Senior Scientific collaborator at the Swiss Tropical and Public Health Institute, University of Basel, Switzerland

Julia Bielicki is Senior Lecturer, St George’s University of London, UK and Consultant in General Pediatrics, Pediatric Infectious Diseases and Pediatric Pharmacology at the University of Basel Children’s Hospital, Switzerland.

12:30-13:00: 3 free oral presentations
                       Moderators: Janneke Brussee  & Stephanie Laer
12:30-12:40: Janneke Brussee: Ivermectin in children: what is the right dose to achieve equivalent exposure coverage in children and adults?
12:40-12:50: Facundo Garcia Bournissen: Use of albendazole in children with asymptomatic toxocariasis
12:50-13:00: Ines Mack: Clavulanate stability in child-appropriate formulations is inadequate for use in treating young children in Asia

13:00-14:30: Lunch, poster viewing session and networking

14:30-16:00: Special topics in paediatric pharmacology
                        Moderators: Ilan Matok & Jenny Kindblom

14:30-15:00: Gideon Koren: Pharmacology of cannabis in adolescents
15:00-15:30: Helle Holst: Child friendly, age-appropriate formulations: how important are excipients?
15:30-16:00: Karel Allegaert: Perinatal use of acetaminophen; a shotgun approach

Information about speakers:

Gideon Koren is Professor at the Maccabi Institute of Research and Innovation at the Tel Aviv University in Israel

Helle Holst is an Associate Professor in the Department of Clinical Pharmacology, Copenhagen, Denmark

Karel Allegaert is Professor of Neonatology at the University of Leuven, Belgium and Faculty at the Erasmus Medical Center-Sophia Children’s Hospital, Rotterdam, the Netherlands

16:00-16:30: Coffee, posters and networking

16:30-18:00: 9 free oral presentations
                       Moderators: Valentina Shakhnovich & Andre Dallmann
16:30-16:40: Kit Wun Kathy Cheung: A comprehensive analysis of ontogeny of renal drug transporters: mRNA analyses, quantitative proteomics and localization
16:40-16:50: Nori Smeets: Ontogeny of human kidney OCT2 expression across the paediatric age range
16:50-17:00: Wei Zhao: Population pharmacokinetic meta-analysis of individual data to design the first randomized efficacy trial of vancomycin in neonates and young Infants
17:00-17:10: Christina Gade: Midazolam pharmacokinetics in children with obesity
17:10-17:20: Valentina Shakhnovich: Prospective evaluation of a population pharmacokinetic model of pantoprazole for obese children
17:20-17:30: Gilbert Koch: Pharmacometric modelling of free thyroxine dynamics after initiation of antithyroid drug treatment in children with Graves’ disease: a tool for personalized drug dosing in children
17:30-17:40: Natalie Dinavitser: Levetiracetam monitoring in breast-milk: high inter-individual variability
17:40-17:50: Andre Dallmann: Physiologically based pharmacokinetic models to predict fetal exposure to antiviral drugs
17:50-18:00: Valery Elie: Population pharmacokinetics of ganciclovir after oral valganciclovir in renal transplant children

FOYER – 08:30-18:00

08:30-18:00: Industry exhibition, Poster exhibition Day 2

13:30-14:30: Poster Viewing Session P62-P118


19:00-01:00: Congress networking event