European Society for Developmental
Perinatal and Paediatric Pharmacology

28 - 30 May 2019, Basel, Switzerland

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Tuesday May 28, 2019

MONTREAL ROOM – 8:00-17:45

08:00-08:45: Registration

08:45-09:00: Welcome. John van den Anker, President ESDP and Jean-Pierre Guignard, founder ESDP

09:00-10:30: Precision medicine in children
                        Moderators: Bruce Carleton  & John van den Anker

09:00-09:30: William Evans: Pharmacogenomics: a cornerstone of precision medicine for childhood cancer
09:30-10:00: Matthias Schwab: Personalized medicine in children: more than just development?
: Gregory Kearns: Personalized medicine in young infants: more than just genetics?

Information about speakers:

William Evans is the Endowed Chair in Pharmacogenomics and former President and CEO of St. Jude’s Children’s Research Hospital in in Memphis, TN, USA

Matthias Schwab is Professor and Chair of Clinical Pharmacology at the Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology in Stuttgart and the Department of Clinical Pharmacology in Tuebingen, Germany

Gregory Kearns is President of the Arkansas Children’s Research Institute and Chief Research Officer at Arkansas Children’s Hospital

10:30-11:00: Coffee, posters and networking

11:00-13:05: Use of modeling in all stages of life
                        Moderators: Evelyne Jacqz-Aigrain & Marc Pfister

: Andre Dallmann: Building the PK-Sim pregnancy model
11:25-11:50: Xiaomei (Mae) Liu: Physiology-based maternal-fetal models: application and regulatory implications
: Wei Zhao: Model-based extrapolation: optimal trial design and personalized dosing in children
: Catherijne Knibbe: Use of bodyweight as dosing scalar in children in the era of obesity
: Catherine Sherwin: How to select datasets for external evaluation

Information about speakers:

Andre Dallmann is a postdoctoral fellow at the University Children’s Hospital Basel, Switzerland

Xiaomei (Mae) Liu is a postdoctoral fellow at the Children’s National Medical Center in Washington, DC, USA

Wei Zhao is Professor and Director of the Institute of Clinical Pharmacy and Pharmacology, Shandong University in Jinan, China

Catherijne Knibbe is Professor of Individualized Drug Treatment, Leiden Academic Centre for Drug Research, the Netherlands

Catherine Sherwin is Director of the Division of Clinical Pharmacology, University of Utah, Salt Lake City, USA

13:05-14:15 Lunch, poster viewing session and networking

14:15-17:15: Research infrastructures to conduct neonatal and paediatric clinical trials
Moderators: Gregory Kearns & John van den Anker

14:15-14:40: Edward Connor: I-ACT
14:40-15:05: Mark Turner: IMI-2
: Sam Maldonado: Industry’s view
: Dionna Green: FDA’s view
: Ralph Bax: EMA’s view
16:20-17:15: Q&A moderated by Gregory Kearns and John van den Anker

Information about speakers:

Edward Connor is Chairman and President of Institute for Advanced Clinical Trials for Children (I-ACT)

Mark Turner is Chair of the European network of pediatric research at EMA (EnprEMA)

Samuel Maldonado is the Vice President and Head of the Pediatric Development Center of Excellence at Johnson & Johnson Pharmaceutical Research and Development

Dionna Green is the Deputy Director of the Office of Pediatric Therapeutics in the Office of the Commissioner at the FDA

Ralph Bax is Head of Pediatric Medicines (ad interim) at the EMA

Gregory Kearns is President of the Arkansas Children’s Research Institute and Chief Research Officer at Arkansas Children’s Hospital

John van den Anker is the Eckenstein-Geigy Distinguished Professor of Paediatric Pharmacology at the University of Basel Children’s Hospital in Switzerland and President of the European Society for Developmental Perinatal and Pediatric Pharmacology (ESDP)

17:15-17:45: 3 free oral presentations 
Moderators: Verena Gotta & Wei Zhao

17:15-17:25: Irmgard Toni: Drug-related hospital admissions in paediatrics – what is preventable?
17:25-17:35: Wei Zhao: Developmental pharmacogenetics of SLCO2B1 on montelukast pharmacokinetics in Chinese children
17:35-17:45: Baset Elzagallaai: Allergy to penicillins in a pediatric population: reported vs true

OSAKA ROOM – 14:15-17:45

14:15-16:15: Novel methods to support paediatric pharmacotherapy
Moderators: Gilbert Koch & Gideon Koren

14:15-14:45: Pablo Sinues: TDM using breath analysis
: Wouter Vaes: How to optimize the use of microtracers in neonatal and pediatric pharmacology
: Beate Wulff: MOA-matching to develop adult pipelines for children with cancer
:  Julia Vogt: Machine learning for clinical data analysis and precision medicine

Information about speakers:

Pablo Sinues is Botnar Research Professor at the University Children’s Hospital Basel, Switzerland

Wouter Vaes is Senior Director Human Biology, the Netherlands Organisation for Applied Scientific Research (TNO), the Netherlands

Beate Wulff is Medical Director in the Innovative Pediatric Oncology Development Team (iPODD), a Pediatric Hematologist-Oncologist and Medical Director in the Innovative Pediatric Oncology Drug Development Team (iPODD) at Roche in Basel, Switzerland

Julia Vogt is Assistant Professor, Department of Mathematics and Computer Science, University of Basel, Switzerland

16:15-16:45: Coffee, posters and networking

16:45-17:45: 6 free oral presentations
                       Moderators: Matthew Peak & Victoria Ziesenitz
16:45-16.55: Theresa Maier: Therapeutic delivery during breastfeeding: a feasibility study
16.55-17:05: Laurens F.M. Verscheijden: Development of a paediatric brain PBPK model in children with and without meningitis
17:05-17:15: Bianca D. van Groen: Dose-linearity of the pharmacokinetics of an intravenous [14C]midazolam microdose in children
17:15-17:25: Pablo Sinues: Progress towards Therapeutic Drug Monitoring via breath analysis
17:25-17:35: Matthew Peak: 3D printed polyethylene oxide oral doses with innovative ‘radiator-like’ design: impact of molecular weight on mechanical and rheological properties and drug release
17:35-17:45: Louise Bracken: Can children swallow tablets? Outcome data from a feasibility study to assess the swallowability and acceptability of different sized placebo tablets in children and young people (Creating Acceptable Tablets - CAT)

FOYER – 08:45-17:30

08:45-17:30: Industry exhibition, Poster exhibition Day 1

13:30-14:15: Poster Viewing Session P01-P61


17:45-19:15: Reception (all participants)

19:30: Faculty and Council dinner (by invitation only)